"DNA repair is a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome. In human cells, both normal metabolic activities and environmental factors such as radiation can cause DNA damage, resulting in as many as 1 million individual molecular lesions per cell per day. Many of these lesions cause structural damage to the DNA molecule and can alter or eliminate the cell's ability to transcribe the gene that the affected DNA encodes. Other lesions induce potentially harmful mutations in the cell's genome, which affect the survival of its daughter cells after it undergoes mitosis. As a consequence, the DNA repair process is constantly active as it responds to damage in the DNA structure. When normal repair processes fail, and when cellular apoptosis does not occur, irreparable DNA damage may occur, including double-strand breaks and DNA cross linkages. This can eventually lead to malignant tumors, or cancer as per the two hit hypothesis.
The book is basic in the sense that it begins at the beginning and is entirely self-contained. It is also comprehensive and contains detailed descriptions of Directions in DNA Repairing. The aim has been to make the subject matter broadly accessible to advanced students, whilst at the same time providing a reference text for graduate scholars and research scientists active in the field.
This book has been written in easy and fluent language expressive and self-explanatory labelled diagrams, concise but not too brief, written to the point starting from fundamentals and finishing to the most advanced and current concepts. All diagrams have been provided with detailed legends. Some diagrams have been drawn the author himself from the original source, while the remaining ones are quoted from the authentic works.
Special effort has been made to appeal to students' natural curiosity and to help them explore the various facets of the exciting subject area of Directions in DNA Repairing. Written in clear, simple language understandable to the general reader, yet in-depth enough for scientists, educators and advanced students. The style is easy to read and suitable for nonnative English speakers and translators with no engineering experience."